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Ethyl beta cyclodextrin is an ethylated derivative of beta cyclodextrin, with tunable hydrophobicity achieved through controlled substitution degrees, allowing it to adapt to diverse formulation requirements across food and pharmaceutical sectors. As a cyclodextrin-based embedding material, it forms inclusion complexes with guest molecules through its hydrophobic internal cavity, delivering functions such as solubilization, stability improvement and release rate regulation for active ingredients. The product is available in different substitution grades to match varied formulation demands in commercial production and R&D scenarios, supporting flexible selection based on specific application targets.
Parameter | Specification |
|---|---|
Product Name | Ethyl Beta Cyclodextrin |
Molecular Formula | C₄₂H₇₀₋ₙO₃₅(C₂H₅)ₙ |
Molecular Weight | 1135.0 + 28.1n |
Appearance | Off-white to yellow powder |
Quality Standard | Enterprise Standard |
The performance of ethyl beta cyclodextrin varies with substitution degree, and the product is divided into two main grades to suit different usage scenarios.
Low-substitution ethyl beta cyclodextrin retains water solubility, making it compatible with aqueous formulation systems. Compared with methylated beta cyclodextrin, this variant has longer alkyl side chains, which expands the adaptation range of its internal cavity and allows it to encapsulate guest molecules with larger molecular dimensions. It retains the core embedding properties of cyclodextrin derivatives, and achieves a balance between water solubility and embedding capacity, serving as a suitable option for formulations that require homogeneous dispersion in aqueous phases.
High-substitution ethyl beta cyclodextrin exhibits stronger hydrophobicity as the number of ethyl substituents increases. Based on its hydrophobic characteristics, this grade can be applied to adjust the release rate of active ingredients, slowing down the diffusion and release process to achieve a sustained release effect. In addition, it can enhance the chemical stability of sensitive active compounds, reducing degradation caused by external environmental factors such as oxidation and light exposure, and extending the effective duration of active components.
Ethyl beta cyclodextrin is used in food and pharmaceutical formulation development, with different grades matching distinct application demands.
In food production and formulation, low-substitution ethyl beta cyclodextrin is used to encapsulate flavor compounds, essential oils and lipophilic nutrients. It reduces the volatilization and oxidative loss of flavor substances during processing and storage, extending the shelf life of food products. Its expanded embedding cavity can adapt to various food-derived active molecules, improving the dispersibility and stability of lipophilic components in water-based food systems. It is applicable for commercial production of beverages, baked goods and functional food products.
In the pharmaceutical sector, low-substitution ethyl beta cyclodextrin is applied for solubilization of poorly soluble drugs, improving the dissolution rate and bioavailability of drug molecules in the human body. High-substitution variants are used in the development of sustained-release preparations, controlling drug release speed through hydrophobic interaction to prolong the duration of drug action and reduce administration frequency. The product can also improve the storage stability of sensitive drug ingredients, reducing degradation caused by light and oxygen factors during storage and transportation.
The product is available in multiple packaging specifications to accommodate different scales of commercial procurement, including 0.1kg per bag, 1kg per bag and 2kg per bag. It should be stored in a sealed condition in a dry environment, away from direct sunlight and moisture, to maintain stable product performance. During transportation and handling, the packaging integrity should be maintained to avoid product contamination or moisture absorption caused by damaged packaging. For orders with special packaging requirements, customized solutions can be discussed based on actual application scenarios.
The core difference lies in solubility and hydrophobic performance. Low-substitution ethyl beta cyclodextrin maintains water solubility and can encapsulate molecules with larger sizes, suitable for aqueous formulation systems. High-substitution variants have stronger hydrophobic properties, which are mainly used for sustained release of active ingredients and stability improvement of sensitive compounds.
Yes, ethyl beta cyclodextrin is applicable for food formulation scenarios. It is commonly used to embed flavor substances, essential oils and fat-soluble nutrients, to reduce component loss during processing and storage, and to improve the stability of active ingredients in food matrices.
Standard packaging specifications include 0.1kg bags, 1kg bags and 2kg bags. For commercial orders with specific volume or packaging requirements, corresponding adjustment schemes can be provided according to actual demand.
