close
Choose Your Site
Global
Social Media
| Quantity: | |
|---|---|
Hyperbranched cyclodextrin (CDP) is a class of cyclodextrin-based polymers that combines the molecular recognition properties of cyclodextrins with the architectural advantages of hyperbranched macromolecules. Synthesized through cross-linking of β-cyclodextrin units, this material retains the inherent hydrophobic cavity structure of native cyclodextrins while introducing additional intermolecular cavities formed by the branched polymer chains. The CAS number for β-cyclodextrin/epichlorohydrin copolymer is 25655-42-9.
The synthesis of hyperbranched cyclodextrin typically involves cross-linking β-cyclodextrin monomers with epichlorohydrin under controlled alkaline conditions. The resulting polymer exhibits a dendritic architecture with multiple cyclodextrin units interconnected via glycerol ether bridges. The molecular weight can be tailored during synthesis, with commercial products ranging from approximately 30 kDa to over 400 kDa depending on reaction parameters. The molecular formula for the repeating cross-linked unit is approximately 1135 + n × (116 + 35.5), where n represents the degree of polymerization.
Hyperbranched cyclodextrin demonstrates several distinct properties compared to conventional single-unit cyclodextrin derivatives. The multi-cavity structure provides higher loading capacity for guest molecules, while the branched architecture contributes to improved water solubility and modified release kinetics. The material appears as a white or almost white amorphous powder and exhibits good solubility in aqueous solutions.
The dual-cavity system—consisting of the intrinsic cyclodextrin cavities and the intermolecular spaces within the branched structure—enables simultaneous encapsulation of multiple guest molecules with different molecular sizes and polarities. This structural feature makes CDP particularly suitable for formulations requiring co-encapsulation of multiple active ingredients or for compounds that do not fit well within single cyclodextrin cavities.
Parameter | Specification |
|---|---|
Product Name | Hyperbranched Cyclodextrin (CDP) |
CAS Number | 25655-42-9 |
Appearance | White or almost white amorphous powder, freely soluble in water |
Assay (dry basis) | ≥98% |
Residual β-Cyclodextrin | ≤2.5% |
Loss on Drying | ≤10% |
Residue on Ignition | ≤3.0% |
Heavy Metals | ≤10 ppm |
Grade | Cosmetic / Industrial grade |
Quality Standard | Enterprise Standard |
Hyperbranched cyclodextrin finds use across multiple industrial sectors due to its encapsulation, solubilization, and stabilization capabilities.
In pharmaceutical applications, CDP serves as a solubility enhancer for poorly water-soluble active pharmaceutical ingredients (APIs). The multi-cavity structure can achieve solubilization factors of 10-fold or higher for certain hydrophobic compounds compared to native β-cyclodextrin. It is also investigated for controlled release formulations and as a component in gene delivery vectors.
The cosmetic industry utilizes hyperbranched cyclodextrin for encapsulating fragrances, essential oils, and active skin care ingredients. The material helps improve ingredient stability, reduce volatility, and enhance skin penetration of hydrophobic actives. Its good water solubility allows easy incorporation into aqueous cosmetic formulations.
Hyperbranched cyclodextrin demonstrates adsorption capacity for organic micropollutants in water, including phenols, amines, and certain dyes. The material can be used in packed column systems for water purification and is regenerable through elution, making it suitable for industrial wastewater treatment applications.
The chiral environment provided by the cyclodextrin units makes CDP useful as a chiral selector in analytical chemistry applications, including capillary electrophoresis and high-performance liquid chromatography (HPLC) for enantiomeric separation of pharmaceutical compounds.
Production of hyperbranched cyclodextrin follows established manufacturing protocols with batch-to-batch consistency verification through comprehensive quality control testing. Each production lot undergoes analysis for assay, residual monomers, moisture content, and heavy metal content. Manufacturers typically maintain ISO 9001 quality management system certification and provide product analysis reports with each shipment.
Hyperbranched cyclodextrin is available in various packaging configurations to accommodate different order quantities. Inner packaging uses polyethylene bags enclosed in aluminum foil bags, with outer packaging in cartons or fiber drums. Standard commercial packaging includes 1 kg, 5 kg, and 25 kg units, with custom labeling available upon request.
The material should be stored in well-closed containers protected from moisture. Under proper storage conditions, the shelf life is typically 24 months from the date of manufacture.
For commercial orders, products are usually shipped within 1-3 working days from the manufacturing facility. Shipping options include air freight, express courier, and sea freight, with FOB, CFR, and CIF terms available.
Sample orders are accepted with a minimum quantity of 0.1 kg, allowing commercial users to evaluate product performance before committing to larger volumes.
We recommend testing sample quality prior to placing bulk orders. Each shipment includes a product analysis report, and the quality of bulk orders corresponds to the quality of pre-shipment samples provided for evaluation.
Technical consultation is available for formulation development and application optimization. Clients can contact the technical support team for guidance on inclusion complex preparation, solubility testing, and compatibility assessment.
Standard commercial orders are typically dispatched within 1-3 working days from order confirmation. For larger quantities or custom specifications, lead times may vary and will be confirmed at the time of quotation.
