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Hydroxypropyl Gamma Cyclodextrin (HP-γ-CD, CAS 128446-34-4) is a cyclodextrin derivative manufactured by XINZHIYUAN, an ISO 9001:2015 certified chemical producer. With an assay of ≥98%, this product features an expanded hydrophobic cavity approximately 0.95 nm in diameter, enabling encapsulation of larger molecular compounds that cannot be accommodated by beta cyclodextrin variants. The hydroxypropyl substitution enhances aqueous solubility compared to native gamma cyclodextrin, supporting its use in formulation development and cell culture research applications.
HP-γ-CD belongs to the family of randomly substituted neutral cyclodextrins. Its molecular structure consists of eight α-D-glucopyranose units linked by α-1,4 glycosidic bonds, with hydroxypropyl groups grafted onto the hydroxyl positions. This modification disrupts the intermolecular hydrogen bonding network, resulting in significantly higher water solubility compared to parent gamma cyclodextrin.
The molecule functions through host-guest complexation: the hydrophobic internal cavity encapsulates lipophilic compounds, while the hydrophilic outer shell maintains dispersion in aqueous environments. This mechanism improves the dissolution rate and apparent solubility of poorly water-soluble active ingredients.
Items | Criteria |
|---|---|
Appearance | White or almost white powder; Odorless, slightly sweet; Freely soluble in water, soluble in ethanol, almost insoluble in acetone |
Water solution pH | pH 5.0-8.5 |
Light-absorbing impurities | max. 0.5 (230 - 660 nm) |
Water | ≤10.0% |
Alpha Cyclodextrin | ≤1.5% |
Residue on ignition | ≤0.2% |
Heavy Metal | ≤10 ppm |
Propylene glycol | ≤0.5% |
Assay | ≥98% |
Hydroxypropoxyl content | 17.5%-29.1% |
The total aerobic microbial count | ≤10³ cfu/g |
The total combined moulds and yeasts count | ≤10² cfu/g |
Escherichia coli | Absence |
Bacterial Endotoxins Test | According to preparation needs <0.01 EU/mg |
Parameter | Value |
|---|---|
Average Molecular Formula | C₄₈H₈₀₋ₙO₄₀ · (C₃H₇O)ₙ |
Average Formula Weight | 1297.2 + n·(58.1) |
Appearance (Colour) | White to off white |
Melting Point | >240°C (dec.) |
Solubility (in 100 cm³ solvent, at 25°C) | Water: > 50g; Methanol: > 50g; Chloroform: < 1.0g |
HP-γ-CD serves as a solubilizing agent and complexation carrier across multiple industrial applications. Its enlarged cavity diameter makes it suitable for encapsulating macromolecular compounds that do not fit within beta cyclodextrin cavities. Typical applications include:
Formulation development: Solubility enhancement for poorly water-soluble active ingredients in parenteral formulations and solid dosage forms
Cell culture research: Use as a solubilization aid for lipophilic compounds in cell culture media
Analytical chemistry: Application as a chiral selector in chromatographic separations
Industrial manufacturing: Use as an embedding agent and stabilizer in substance production
The product is available in standard pack sizes of 1 kg, 5 kg, and 10 kg, with custom packaging options available upon request. Inner packaging consists of PE bags with aluminum foil bag layers, while outer packaging uses cartons or fiber drums.
Storage conditions require well-closed containers protected from moisture exposure. The tariff number for shipping classification is 3505100000.
Gamma cyclodextrin contains eight glucose units, creating a larger internal cavity diameter of approximately 0.95 nm compared to beta cyclodextrin's 0.78 nm. This allows gamma cyclodextrin to encapsulate larger molecular weight compounds that cannot form inclusion complexes with beta cyclodextrin.
Hydroxypropyl substitution disrupts the crystalline structure of native cyclodextrin, significantly increasing aqueous solubility. HP-γ-CD exhibits solubility exceeding 50 g per 100 cm³ of water at 25°C, compared to approximately 23 g/100 cm³ for native gamma cyclodextrin.
Standard pack sizes start at 1 kg. The product is maintained in stock for immediate shipment. Custom packaging configurations can be arranged for volume orders.
Each batch undergoes testing for assay, purity, moisture content, microbial limits, and heavy metal content according to the specifications listed above. The manufacturing facility operates under ISO 9001:2015 quality management systems.
