Hydroxypropyl-beta-cyclodextrin (HPBCD)

Hydroxypropyl-beta-cyclodextrin (HPBCD) are purified polydisperse products resulting from the controlled reaction of propylene oxide and native beta-cyclodextrin. Oral Grade Hydroxypropyl Beta Cyclodextrin is itself very soluble in water (greater than 500 mg/ml at room temperature compared to 18 mg/ml for beta-cyclodextrin), and is used for molecular encapsulation of a variety of sparingly water compounds to enhance the aqueous solubility of the encapsulated compound

HPBCD cyclodextrinis easily soluble in water, and its solubility is more than 50% (w/v) or even more than 75% (w/v) at room temperature. When its concentration is lower than 40%, it has good fluidity and is not viscous. When the solubility of insoluble drugs cannot be effectively increased by traditional methods, Hydroxypropyl-beta-cyclodextrin (HPBCD) can be considered to achieve the therapeutic effect. It solubilizes highly lipid soluble drugs, which can reduce stimulation and improve stability, but its solubilization effect is still limited. It has obvious solubilization effect only when the pH value range of the solution is 4.5-4.8.

Hydroxypropyl-beta-cyclodextrin manufacturer-Shandong Binzhou Zhiyuan Biotechnology Co., Ltd which has completed registration with FDA, and the registration information is as follows:

Company name: Shandong Binzhou Zhiyuan Biotechnology Co., Ltd

FDA ESTABLISHMENT IDENTIFIER (FEI No.)：3011680310

ESTABLISHMENT ADDRESS: Boxing Economic Development Zone,, Binzhou, Shandong 256500, China (CHN)

DUNS: 548171477

Oral Grade Hydroxypropyl Beta Cyclodextrin is a cyclic oligosaccharide. Usually, it is composed of 6, 7, or 8 glucose units connected to the crystal through a, 1 → 4 bond ring phase.Hydroxypropyl-beta-cyclodextrin (HPBCD) has the characteristics of solubilization, antioxidant, odor removal, sustained release, and targeted delivery, and is an ideal injection solubilizer and drug excipient.

1. Increase the water solubility of poorly soluble drugs

Oral Grade Hydroxypropyl Beta Cyclodextrin is easily soluble in water, and the solubility at room temperature is generally greater than 50g/100mL, and can even reach more than 80g/100mL. When the concentration is less than 40%, the fluidity is good and the viscosity is not large. Used in the pharmaceutical industry to improve the solubility of drugs without the use of organic solvents, surfactants and lipids. It can significantly increase the water solubility of poorly soluble drugs after being enveloped with it. After the drug forms a complex with hydroxypropyl-β-cyclodextrin（hbcd）, its concentration increases linearly with the increase in hpbcd cyclodextrin concentration.

2. Increase drug stability and improve drug bioavailability

During the storage process of drugs, they will be affected by many factors such as light, heat, humidity, etc., which directly affect the quality of drugs. Therefore, stability is an important indicator. After the hydroxypropyl-beta-cyclodextrin (HPBCD) is incorporated into the drug, the drug enters the cavity, which can prevent the drug from volatilization, sublimation, oxidation and photolysis.

The drug enclosed with hpbcd cyclodextrin has fast dissolution rate and fast release, and can increase the absorption of the drug by the organism, which is beneficial to improve the bioavailability of the drug.

3. Reduce the toxic and side effects of drugs

Complexing insoluble drugs and switching the route of administration can significantly reduce the toxicity and irritation of the drugs to the human body.

Hydroxypropyl-beta-cyclodextrin (HPBCD) can be used for oral drugs, mucosal drug delivery systems (including nasal mucosa, rectum, cornea, etc.), transdermal drug delivery systems, carriers of lipophilic targeted drugs, and can also be used as protein protective agent and stabilizer.

Packing : 1kg/2kg/10kg/20kg/drum or carton

Storage: Preserve well-closed containers protect from moisture.

Does your company is a factory or trade company?

We are Manufacturer, we have production experience of over 13 years with a high reputation and cognition degree in the cyclodextrin field.

What's the main advantages about your Oral Grade Hydroxypropyl Beta Cyclodextrin?

Factory direct sale,we can provide you high quality product and competitive price.

What's the quality assurance you provided?

Established a procedure to check products at all stages of the manufacturing process-raw materials, process materials, validated or tested materials finished goods etc.. Besides, we have also developed a procedure which identifies the inspection and test status of all stages of the manufacturing process.

How do you control quality?

100% inspection in assembly lines. All controls, inspection, equipment, fixtures, total production resources and skills are inspected to ensure they consistently achieve the required quality levels. our product is under the supervision of QA and QC,firmly conforms to GMP standard.

Can purchaser come to audit?

We warmly welcome customers' audit,it's an effective way to build a better business relationship.